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Semaglutide (Wegovy, Ozempic) is a medicine used for weight loss in specific patients, and to lower blood sugar levels and reduce the risk of major cardiovascular events such as heart attack or stroke in type two diabetes patients. Semaglutide is a GLP-1 agonist and works by increasing insulin release, lowering the amount of glucagon released, delaying gastric emptying and reducing appetite.
Semaglutide is not for use in people with type 1 diabetes.
Each of the different brands of semaglutide (Wegovy, Ozempic, Rybelus) are FDA approved for different conditions.
Used to help control blood sugar levels in type 2 diabetic patients, it is used together with diet and exercise. It is also used to reduce the risk of major cardiac events such as heart attack and strokes in type 2 diabetic patients who already have cardiovascular disease. Used for weight loss for patients who have an initial BMI (body mass index) of 30kg/m2 or greater or patients who have a BMI of 27kg/m2 or greater and also have least one weight-related condition, such as high blood pressure, type 2 diabetes and high cholesterol. It is use together with diet and exercise.
Semaglutide works to lower high blood sugar by increasing the amount of insulin that is released, lowering the amount of glucagon released and by delaying gastric emptying. Semaglutide also controls appetite and so helps you reduce the amount of food that you want to eat. Semaglutide is a glucagon-like peptide-1 (GLP-1) agonist
Semaglutide side effects
Get emergency medical help if you have signs of an allergic reaction: hives, itching; dizziness, fast heartbeats; difficult breathing; swelling of your face, lips, tongue, or throat.
Serious side effects of semaglutide may include:
call your doctor at once if you have:
- vision changes;
- unusual mood changes, thoughts about hurting yourself;
- pounding heartbeats or fluttering in your chest;
- a light-headed feeling, like you might pass out;
- signs of a thyroid tumor–swelling or a lump in your neck, trouble swallowing, a hoarse voice, feeling short of breath;
- symptoms of pancreatitis–severe pain in your upper stomach spreading to your back, nausea with or without vomiting, fast heart rate;
- gallbladder problems–upper stomach pain, fever, clay-colored stools, jaundice (yellowing of the skin or eyes);
- low blood sugar–headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery;
- kidney problems–swelling, urinating less, feeling tired or short of breath; or
- stomach flu symptoms–stomach cramps, vomiting, loss of appetite, diarrhea (may be watery or bloody).
Common side effects of semaglutide may include:
- low blood sugar (in people with type 2 diabetes);
- upset stomach, heartburn, burping, gas, bloating;
- nausea, vomiting, stomach pain, loss of appetite;
- diarrhea, constipation;
- stomach flu symptoms; o
- headache, dizziness, tiredness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.